Comparison of laboratory-based and non-laboratory-based WHO cardiovascular disease risk charts: a population-based study

Background: Determining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions
in high-risk groups. However, laboratory testing may be impractical in countries with limited resources. This study
aimed at comparison and assessment of the agreement between laboratory-based and non-laboratory-based WHO
risk charts models.
Methods: This study was performed using the baseline data of 8138 participants in the pars cohort study who had
no history of CVD and stroke. The updated 2019 WHO model was used to determine the 10-year fatal and non-fatal
CVD risks. In general, there are two types of new WHO risk prediction models for CVD. The scores were determined
based on age, sex, smoking status, diabetes, Systolic Blood Pressure (SBP), and total cholesterol for the laboratory-
based model and age, sex, smoking status, SBP, and Body Mass Index (BMI) for the non-laboratory-based model. The
agreement of these two models was determined via kappa statistics for the classified risk (low: < 10%, moderate:
10–< 20%, high: 20%). Correlation coefficients (r) and scatter plots was used for correlation between scores.

Results: The results revealed very strong correlation coefficients for all sex and age groups (r = 0.84 for
males < 60 years old, 0.93 for males 60 years old, 0.85 for females < 60 years old, and 0.88 for females 60 years old).
In the laboratory-based model, low, moderate, and high risks were 76.10%, 18.17%, and 5.73%, respectively. These
measures were respectively obtained as 77.00%, 18.08%, and 4.92% in the non-laboratory-based model. Based on risk
classification, the agreement was substantial for males < 60 years old and for both males and females aged 60 years
(kappa values: 0.79 for males < 60 years old, 0.65 for males 60 years old, and 0.66 for females 60 years old) and
moderate for females < 60 years old (kappa = 0.46).
Conclusions: The non-laboratory-based risk prediction model, which is simple, inexpensive, and non-invasive, classi-
fies individuals almost identically to the laboratory-based model. Therefore, in countries with limited resources, these
two models can be used interchangeably.

Association between Nontraditional Risk Factors and Calculated 10-Year Risk of Atherosclerotic Cardiovascular Disease in a Large General Population: Based on the Pars Cohort Study


Pooran Mohsenzadeh, Ali Ardekani, Hossein Poustchi, Zahra Mohammadi, Seyed Reza Abdipour Mehrian, Hamed Bazrafshan Drissi, Zahra Rahimian, Erfan Taherifard, Ali Nabavizadeh, Alireza kamalipour, Bita Mesgarpour, Fatemeh Malekzadeh & Hossein Molavi Vardanjani


Background: While the traditional risk factors of atherosclerotic cardiovascular disease (ASCVD) have been well-established, the evolving role of nontraditional risk factors is not apparent. This study aimed to evaluate the association between nontraditional risk factors and the calculated 10-year ASCVD risk in a general population.

Methods: This cross-sectional study was conducted using the Pars Cohort Study data. All inhabitants of the Valashahr district in southern Iran, aged 40–75 years, were invited (2012-2014). Patients with a history of cardiovascular disease (CVD) were excluded. The demographic and lifestyle data were collected using a validated questionnaire. Multinomial logistic regression analysis was used to evaluate the association between the calculated 10-year ASCVD risk and the nontraditional risk factors of CVD, including marital status, ethnicity, educational level, tobacco and opiate consumption, physical inactivity, and psychiatric disorders.

Results: Of 9264 participants (mean age =52.2±9.0 y; 45.8% male), 7152 patients met the inclusion criteria. In total, 20.2%, 7.6%, 36.3%, 56.4%, and 46.2% of the population were cigarette smokers, opiate consumers, tobacco consumers, ethnically Fars, and illiterate, respectively. The prevalence rates of low, borderline, and intermediate-to-high 10-year ASCVD risks were 74.3%, 9.8%, and 16.2%, respectively. In multinomial regression, anxiety (adjusted odds ratio [aOR], 0.58; P<0.001) was significantly associated with a lower ASCVD risk, whereas opiate consumption (aOR, 2.94; P<0.001) and illiteracy (aOR, 2.48; P<0.001) were significantly associated with a higher ASCVD risk.

Conclusion: Nontraditional risk factors are associated with the 10-year ASCVD risk and, thus, might be considered besides traditional ones for ASCVD in preventive medicine and health policies.

Scientifc Reports

Agreement between laboratory‑based and non‑laboratory‑based Framingham risk score in Southern Iran


Fatemeh Rezaei1 , Mozhgan Seif2 , AbdullahGandomkar3 , Mohammad Reza Fattahi4 & Jafar Hasanzadeh5


Introduction: Estimation of the risk of cardiovascular diseases (CVD), may lead to prophylactic therapies. This study aims to compare and evaluate the agreement between CVD prediction of Iran Package of Essential Non-communicable Disease (IraPEN) and Framingham risk score (FRS).

Methods: All 40-79 years old participants in the Yazd Health Study who did not have a history of CVD were included. The 10-years risk of CVD was estimated by the laboratory (IraPEN), non-laboratory WHO-EMR B and FRS. The risk was classified into low, moderate and high-risk groups. Cohen’s weighted kappa statistics were used to assess agreement between tools. To assess discrepancies McNemar’s χ2 test for paired data was used. P values < 0.05 were considered statistically significant.

Results: In total, 2103 participant was included and the risk scores were calculated. Of them, 26.5% were stratified as high risk by FRS, compared with 6.1% by IraPEN. A slight agreement (37.9%) was observed (kappa 0.17, P < 0.0001), in other words. This discrepancy between IraPEN vs. FRS was seen in both sexes (P < 0.0001), although in women the agreement ratio was higher (52.1% vs. 21.3%). The discrepancy between FRS and IraPEN in categorizing people at risk of CVD was 55.5%, (P < 0.0001) but this was not significant between IraPEN and non-laboratory WHO-EMR-B (World Health Organization – Eastern Mediterranean Regional-B group countries) score (P < 0.523; discrepancies, 5.8%).

Conclusion: Our study shows a slight agreement between various CVD risk scores. Thus, reviewing the IraPEN and using alternative tools for the low-risk group should be considered by decision-makers. It is important to use a more reliable score for nation-wide risk assessment.


Prediction of Cardiovascular Disease Mortality in a Middle Eastern Country: Performance of the Globorisk and Score Functions in Four Population-Based Cohort Studies of Iran

15-Year lipid profile effects on cardiovascular events adjusted for cardiovascular risk factors: a cohort study from Middle-East

Trends of Major Cardiovascular Risk Factors in Iranian Population During Years 2001-2013: The Isfahan Cohort Study

The association between the serum 25-hydroxyvitamin D level and cardiovascular events in individuals with and without metabolic syndrome

Do Cardiometabolic Risk Factors Relative Risks Differ for the Occurrence of Ischemic Heart Disease and Strokejpg

Do Cardio metabolic Risk Factors Relative Risks Differ for the Occurrence of Ischemic Heart Disease and Stroke?