Dr. Fatemeh Torkamanasadi was appointed as HBCS supervisor

Regarding the retirement of Dr. Fariba Karamet, Dr. Fatemeh Torkamanasadi was appointed as Famenin Brucellosis Cohort Study supervisor.

Removal of livestock suffered brucellosis

In accordance with the research projects related to the Famenin brucellosis cohort in a research entitled: Investigation of the prevalence of brucellosis in domestic animals (cows, sheep, and goats) of Famenine City in 2018 and according to the approval of the scientific results of this project by the veterinary organization of Hamadan, after examining 1758 animals in Feminine city, 23 animals, including 2 goats and 21 sheep, were diagnosed positive for brucellosis and were removed from the breeding cycle under the supervision of the veterinary organization and with the consent of the livestock owners.

Hand holding a blood glucose meter measuring blood sugar, the background is a stethoscope and chart file

Increased Dietary Intake of L-Arginine Linked to Increased Risk for Type 2 Diabetes

Hand holding a blood glucose meter measuring blood sugar, the background is a stethoscope and chart file

Hand holding a blood glucose meter measuring blood sugar, the background is a stethoscope and chart file

People who consume higher levels of dietary L-arginine, an amino acid involved in the metabolism of glutamate and proline, were found to have an increased risk of developing type 2 diabetes (TD2), according to research results published in BMC Endocrine Disorders. In the context of total protein intake as well as L-arginine-to-protein ratio, however, no association was found between increased L-arginine intake and risk of T2D.

Research has suggested that L-arginine may be involved in nitric oxide-dependent pathways that affect the homeostasis of glucose and insulin. Currently, little data from long-term studies elucidate the effects of L-arginine intake on the risk for T2D.

In a recent prospective cohort study, a team of researchers from Iran examined the potential impact of dietary L-arginine intake on T2D incidence in 2139 adults (mean age, 38.9 years; 54.6% women) who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS) and who did not have T2D at baseline.

The researchers assessed typical daily intake of protein and L-arginine using a 168-item validated food frequency questionnaire. Participants were considered to have developed T2D over the follow-up period if they were using an antidiabetic drug, had a fasting serum glucose of at least 126 mg/dL, and/or had a 2-hour post-challenge glucose level of at least 200 mg/dL.

Over the median 5.8-year follow-up period, the mean daily intake of dietary protein was 77.2±22.4 g, and the mean daily intake of L-arginine was 4.05±1.50 g. Participants with and without diabetes had the same mean daily intake of L-arginine during the study (4.05±1.5 g for each).

In the crude model, the researchers found no significant association between L-arginine intake and T2D risk in the second tertile (hazard ratio [HR], 0.83; 95% CI, 0.55-1.26) or the third tertile (HR, 1.06; 95% CI, 0.71-1.56) of L-arginine intake (P =.43).

Another analysis was conducted and adjusted for diabetes risk score; physical activity; sex; age; smoking; total energy intake; and intake of carbohydrates, fiber, fats, lysine, and total protein. In this adjusted model, there was a significantly increased risk of T2D in the highest L-arginine intake tertile (mean, >5.4 g/d) compared with the lowest tertile (mean, 2.69 g/d; HR, 2.71; 95% CI, 1.20-6.09; P =.02).

In contrast, there was no association between total protein and ratio of L-arginine-to-total protein intake and T2D incidence (HR, 1.89; 95% CI, 0.99-3.60; P =.052).

A limitation of this study was the lack of adjustment for other factors in food sources of L-arginine that could have affected T2D risk. The lack of data about serum L-arginine levels represented another study limitation.

The researchers noted that given the increased interest in ingesting L-arginine as a “dietary supplement, and also the limited data in case of the potential association between dietary L-arginine and cardio-metabolic outcomes especially T2DM, further cohort studies are required to clarify the possible association.”

Mirmiran P, Bahadoran Z, Gaeini Z, Azizi F. Habitual intake of dietary L-arginine in relation to risk of type 2 diabetes: a prospective study. BMC Endocr Disord. 2021;21(1):113. doi:10.1186/s12902-021-00774-x


The number of Proposals

44 proposals has been approved in Tabari Cohort Research Center till now


Beginning of the reassessment phase of the Adult Tabari Cohort Study Center

The Adult Cohort Research Center has started its own active phase on 22nd November, 2021. The first participants registered In Tabari Cohort Research Center on Monday, 22nd November, 2021 and the relevant questionnaires have been completed for them after doing routine tests and having breakfast.

Short sleep is associated with higher prevalence and increased predicted risk of cardiovascular diseases in an Iranian population: Fasa PERSIAN Cohort Study

It can be said that short sleep is related to higher prevalence and increased risk of cardiovascular diseases in the Iranian population.

Cardiovascular diseases are the leading cause of death worldwide. One of the common factors that may affect cardiovascular disease risk factors is sleep disorder. Factors affecting a person’s sleep may be different in different cultures. In this research, which was conducted on more than 10,000 residents of the Shasheda region of Fasa. The results showed that people who sleep less than 6 hours have a higher prevalence of cardiovascular diseases, including heart attacks and high blood pressure, than people who sleep 7-8 hours a day. Also, the researchers of this study stated that after calculating the 10-year cardiovascular risk of people, it was observed that people who sleep less than 6 hours have a higher risk of developing cardiovascular diseases in the next 10 years than people who sleep 7-8 hours.

Following the Famenin brucellosis cohort studies

Following the Famenin brucellosis cohort studies, we designed some another research programs to gain more extra data about the risk factors related the Brucellosis disease in Famenin.

Our main projects are as below:

  1. Evaluation of the incidence, relapse, clinical manifestations and complications of brucellosis during two years among participants in the brucellosis cohort study of Famenin.
  2. Confirmation the results of seropositive samples collected from Famenin brucellosis cohort and determination of their species by PCR technique.
  3. Investigation and follow up of brucellosis disease in seropositive participants in Famenin cohort of brucellosis and their families using culture and serology methods.
  4. A survey of seroprevalence of brucellosis in domestic livestock (cattle, sheep and goats) in Famenin city, 2019.
  5. Evaluation of Brucella infection in milk of domestic animals of Famenin city and its comparison with the results of serological tests in the same animal population.
  6. Investigation and evaluation of dietary exposure to tetracycline, oxitetraciclin and chlortetracycline antibiotic residues in domestic animal’s milk in Famenin.
  7. Isolation of Brucella bacteria from positive serological samples collected from Hamadan province and Famenin brucellosis cohort by culture and genetically confirmation and determination of their species by PCR technique.