Introduction: The safety and health of food products are essential in the food industry, and the risk of contamination from various contaminants must be evaluated. Exposure to HMs from the environment (especially food) causes various adverse effects on the body and increases the risk of cardiovascular disease (CVD).

Material and method: Volunteers in the study comprised both healthy individuals and those with CVD. Patients were chosen using a cohort database of CVD individuals. A random choice of samples was conducted. Medical information (individuals with CVD) related to the participants was obtained from the Hoveyzeh Cohort Study Center. CVD-HM relationships were assessed using various machine-learning techniques.

Result: Based on the results of the GAM statistics approach, the baseline levels (β) of As, Cd, and Cr in rice have been calculated to be 1.05, 1.19, and 1.11, respectively. Based on the investigation’s results, rice acts as a mediator between high-magnitude actions and the prevalence of CVD. Eating rice increases the probability of CVD by 0.18 and raises As eating by 0.494. The results showed that rice consumption in the research area is not associated with non-carcinogenic and carcinogenic risk (CRs and ILCRs for both categories were less than 1∗10^-6).

Conclusion: There was neither a carcinogenic nor non-carcinogenic threat to adults or children and many hazardous HMs existed at the accepted thresholds. A notable relationship was seen between rice contaminated with HM and CVD.