Purpose: Rhinosinusitis encompasses a group of conditions characterized by inflammation of the nasal mucosa and paranasal sinuses, impacting the quality of life for those affected. This study was designed to assess the quality of life in the general population using the SNOT-22 questionnaire. This study was designed to assess quality of life among the general population using the SNOT-22 questionnaire, which is a tool for measuring quality of life related to rhinological issues.

Material and methods: This population-based cross-sectional study was conducted as part of the baseline assessment for the Hoveyzeh cohort study, focusing on adults aged 35-70 in southwest Iran. Data related to socioeconomic factors, demographic characteristics, and anthropometric measurements were gathered. Subsequently, a random sample of 1324 individuals participated in the study, completing the Self-reported SNOT-22 questionnaire.

Result: The mean age of 1324 participants was 49.92 ± 8.97 years, and about 60 % were women. The average SNOT-22 score was 7.84 ± 10.78. Approximately 34 % of the participants had an abnormal score on the SNOT-22 questionnaire. These participants were assessed for domains related to nasal, otologic, sleep and emotional symptoms. The most common issues reported were sneezing, dizziness or vertigo, waking up tired, and feelings of sadness, respectively. We observed that the odds of having an abnormal SNOT-22 scores were 62 % higher in women compared to men.

Conclusion: Our results revealed a relatively higher prevalence of abnormal SNOT-22 scores, especially among women. Therefore, designing and implementing therapeutic and educational interventions for these people seems necessary.

Keywords: Adult; Chronic rhinosinusitis; Cohort study; Iran; Quality of life; SNOT-22.