Authors
Gholamreza Asadikaram1,2 | Maryam Ram3 | Alireza Izadi4 |
Mahmood Sheikh Fathollahi5,6 | Mohammad Hadi Nematollahi2 |
Hamid Najafipour7 | Bidollah Shahoozehi2 | Mahboobeh Mirhoseini3 |
Mohammad Masoumi8 | Nader Shahrokhi7 | Mohammad Kazemi Arababadi6,9
Affiliations
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Affiliations
1
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences,
Kerman, Iran
2
Department of Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
3
Department of Biochemistry, Taft Payam Noor University, Yazd, Iran
4
Department of Medical Mycology and Parasitology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
5
Department of Epidemiology and Biostatistics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
6
Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences,
Rafsanjan, Iran
7
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
8
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
9
Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Kerman, Iran
Abstract
Background: Obesity increases the risk of diabetes mellitus (DM) and
hypertension. We aimed to analyze the serum levels of cytokines that have
relevance to the pathologies including, interleukin‐4 (IL‐4), transforming
growth factor‐β (TGF‐β), interferon‐γ (IFN‐γ), and IL‐6 cytokines of overweight
men with DM and/or hypertension.
Methods: The study collected serum from 164 men. The sample population
contained, 54 overweight men without DM or hypertension (control [CTL]
group), 36 men with both DM and hypertension (DH group), 20 men with DM
but no hypertension (D group), and 54 had hypertension without DM (H).
Results: The main results showed that the concentration of IFN‐γ in the DH
group was significantly higher than the D, H, and CTL groups, IL‐6 in DH and D
groups was significantly lower than the CTL group. The serum level of TGF‐β and
IL‐4 cytokines did not show any significant differences across the four groups.
Serum levels of IL‐6 were also significantly lower in untreated patients in D group
than controls and in DH when compared with H groups.
Conclusion: In conclusion, it appears that the proinflammatory and anti‐
inflammatory cytokines either play a significant role in the pathogenesis of
hypertension and DM or serve as markers for these pathologies. Accordingly