Gozashti Mohammad Hossein a, Shafiei Maryam a, Esmaeilian Saeed b, Najafipour Hamid a,Mashrouteh Mahdieh
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
a Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
b Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
c Research Center for Modeling in Health, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Ira
Introduction: Latent autoimmune diabetes in adults [LADA] is a type of autoimmune diabetes in adults
that is usually identified by positive GAD-antibody [glutamic acid decarboxylase]. Epidemiological
studies show that this disease has no identified prevalence and incidence in Asia due to the various
criteria in diagnosing the disease.
Methods: 500 patients with type 2 diabetes based on American Diabetes Association [ADA] criteria and
age of diabetes onset above 35 years old who needed no insulin until at least 6 months after the diagnosis
of diabetes were selected from KERCADR Study and their anti-GAD serum level was determined.
Results: From 500 patients, 429 ones [85%] were negative and 71 ones [14.2%] were positive for GAD
antibody. The prevalence of latent autoimmune diabetes was higher in the age group of 50–59 years
compared to the other age groups. There was no significant correlation between LADA and hypertension,
family history of diabetes, cigarette smoking and tobacco use.
Conclusion: The prevalence rate of latent autoimmune diabetes in adults in patients with type 2 diabetes
was 14.2% and we could not find any relationship