Authors

Fatemeh Safavi1, Gholamreza Yousefzadeh, Ph.D.2, Mostafa Shokoohi, M.Sc.3, Sadaf Safavi, M.D.4,Hamid Najafipour, Ph.D.5, Mitra Shadkam Farokhi, M.Sc.

Affiliations

Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

1. Student of Dentistry, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
2. Assistant Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
3. Researcher, Research Center for Modeling in health, Institute for Future Studies in Health, Kerman University of Medical
Sciences, Kerman, Iran
4. General Practitioner, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
5. Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
6. Research assistant, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
*Corresponding author; e-mail:shokoohi.mostafa2@gmail.com

Abstract

Background & Aims: Metabolic syndrome is composed of interrelated cardiovascular and cardiometabolic
risk factors. Moreover, recent researches have illustrated the association of systemic diseases and
periodontitis. Thus, the early diagnosis of this syndrome, as a cardiometabolic risk factor, seems necessary.
The aim of this study was to evaluate the prevalence of metabolic syndrome in patients with periodontal
disease.
Methods: In this cross-sectional study, 900 subjects from the data bank of the Kerman Coronary Artery
Disease Risk Study (KERCADRS), Iran, were assessed. The community periodontal index (CPI) was used
as the evaluation tool for periodontal treatment needs and health condition . The control group consisted of
healthy individuals.
Results: The prevalence of metabolic syndrome among patients with periodontal disease was significantly
higher than the healthy group (53.6% vs. 33.1%, P < 0.001). High waist circumference, triglyceride disorder,
high fasting blood sugar (FBS), and high blood pressure were significantly higher in patients with
periodontal disease (P < 0.05). After controlling the effect of confounding variables (age, gender and BMI),
the adjusted odds ratio of existence of periodontal pockets were 1.58 (95% CI: 1.1-2.2, P = 0.012) for
metabolic syndrome patients.
Conclusion: Our results showed a high prevalence of cardiovascular disease risk factors among patients
with periodontal disease. Therefore, screening these patients for cardiovascular disease risk factors is
suggested.
Keywords: Metabolic syndrome, Periodontal disease, Cardiovascular diseases, Risk factors, Iran