Aram-Ahmaddi M., B.Sc.1 Bahrampour A., Ph.D.2*, Najafipour H., Ph.D.3
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
1. MSc Student of Biostatistics, Research Center for Modelling in Health Institute for Future Studies in Health and Epidemiology &
Biostatistics Department, School of Health Medical Sciences, Kerman, Iran
2. Professor of Bostatistics, Physiology Research Center and Epidemiology & Biostatistics Department, School of Health, Kerman
University of Medical Sciences, Kerman, Iran
3. Professor of Physiology, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Background & Aim: Diabetes is one of the chronic diseases with no curative treatment; also, it is the most
common cause of amputation, blindness and chronic renal failure and the most important risk factor of heart
diseases. Logistic regression is one of the statistical analysis models for predicting that can be used to find
out the relationship between dependent and predictor independent variables and control of the confounding
variables. The aim of this study was to determine the rate of effective variables on diabetes and estimation of
the logistic regression model for predicting.
Methods: 5357 persons in Kerman city, Iran, were enrolled. Diabetes considered as the response variable
and weight, height, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio
(WHR), age, gender, occupation, education, drugs, drug abuse, activities, systolic and diastolic blood
pressure, and levels of total cholesterol, the high-density lipoprotein (HDL), the low-density lipoprotein
(LDL), and triglycerides were considered as independent variables in the model. Measures of sensitivity,
specificity, accuracy, Kappa measure of agreement and ROC (receiver operating characteristic) curve was
applied for determining the power of test.
Results: The Sensitivity, specificity, accuracy rate, Kappa measure of agreement and area under the ROC
curve for the model were 0.764, 0.725, 0.731, 0.312 and 0.822, respectively. The following variables were
significant according to their impact and their importance, respectively: WHR (β = 2.66, OR=14.32), antihypertensive drug (β =1.279, OR= 3.59), sex (β =0.707, OR= 2.028), level of education, walking and cycling
(β = 0.136, OR= 1.146), waist circumference (β =0.12, OR= 1.127), weight (β = 0.112, OR= 1.118), BMI (β
= 0.053, OR= 1.054), systolic blood pressure (β =0.052, OR= 1.054), age (β =0.046, OR= 1.047), diastolic
blood pressure (β =0.043, OR= 1.044), total cholesterol (β = 0.003, OR= 1.003), triglycerides (β =0.01, OR=
1.011), LDL (β = 0.001, OR= 1.001), hip circumference (β = – 0.025, OR= 1.025), height (β = -0.071, OR=
0.932), HDL (β = -0.078, OR= 0.925), an intense 10-minute work activities (β = -0.507, OR=0.602).
Conclusion: According to the criteria of accuracy and power of prediction, and considering ROC curve
value (0.822) which could perform test accuracy as well for the diagnosis of diabetes, the logistic regression
model was an appropriate model for the prediction of diabetes in this study.
Keywords: Logistic regression, Diabetes, Discrimination, Calibration
No.24, Aarabi St, Yaman St, Velenjak, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Postal Code: 1985717413, P.O Box: 19395-4763