Authors
Mitra Samareh Fekri1, Mostafa Shokoohi2, Mohammad-Hossein Gozashti1, Saeed Esmailian3, Nasrollah Jamshidian3,
Malihe Shadkam-Farokhi1, Mohammad-Reza Lashkarizadeh4, and Reza Malekpour Afshar1
Affiliations
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Affiliations
1 Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
2 Research Center for Modeling in Health, Kerman University of Medical Sciences, Kerman, Iran
3 Research Committee, Kerman University of Medical Sciences, Kerman, Iran
4 Department of Thoracic Surgery; Kerman University of Medical Sciences, Kerman, Iran
Abstract
About 8% of the general population suffers from autoimmune diseases, from which 78%
are women. One of the most important causes of thyroid diseases is autoimmunity in origin,
and it seems that people with thyroid diseases present more signs of asthma. This study was
therefore designed to investigate the frequency of autoimmune thyroid diseases in women
suffering from bronchial asthma.
In a cross-sectional study, 100 women with asthma and 100 women as control group
were tested for thyroid function and anti-thyroid peroxidase antibody (anti-TPO Ab)
measurements. The asthmatic patients were selected based on having chronic cough,
dyspnea, wheezing and clinical examination of the chest. The diagnosis was confirmed by
pulmonary function tests. Blood tests were done by electrochemiluminescence immunoassay
method.
No hyperthyroid patient was found in either group. Serum TSH and Total T4 levels were
not statistically different between the two groups, but serum anti-TPO Ab levels in women
with asthma (74±13.6 IU/ml) was significantly higher than control group (45.24±10.56
IU/ml). After adjusting the effect of age and BMI, the relationship between asthma and anti-
TPO Ab (>50 IU/ml) was statistically significant (OR=3.3, P<0.01).
Positive anti-TPO Ab in asthmatic patients may show presence of a hidden autoimmune
thyroiditis in these patients. We suggested checking asthmatic patients for thyroid diseases.
Keywords: Anti-thyroid peroxidase antibody; Asthma; Thyroid function test; Women