Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Department of internal Medicine, Ayatollah Rouhani Hospital,
Department of Community Medicine, Social Determinants of Health (SDH) Research Center,
Department of Psychiatry, Social Determinants of Health(SDH) Research Center,
Faculty of Medicine, Babol University of Medical Sciences, Babol, I.R. Iran
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Introduction: Vitamin D receptors are widespread in brain tissue, and the active form of vitamin D has been documented for its neuroprotective effects. This study was conducted to determine the association between vitamin D level and cognitive disorders. Materials and Methods: This descriptive–analytical cross sectional study was conducted within the framework of the “Amikola Health and Aging Project (AHAP)”, (2011-12), conducted on 1616 older people, aged>60 years in the city of Amirkola, Iran. Serum levels of vitamin D were measured in morning blood samples and mental status was investigated using Mini-Mental State Examination (MMSE). Data was analyzed with T test, ANOVA and Chi-square, and P-values <0.05 were considered significant. Results: The mean age of study participants was 68.81±7.1 years. Among them 509 (31.5%) had cognitive impairment and 1103 (68.4%) did not. There was significant association between serum vitamin D level and normal and abnormal MMSE in women (P=0.029), but not in men (P=0.49). Mean serum vitamin D level in participants with normal MMSE was 34.45±32.79 ng/ml and in participants with abnormal MMSE was 32.80±29.39 ng/ml but this finding was not significant (P=0.31). Conclusions: Serum vitamin D level in older persons with normal MMSE was higher than in those with abnormal MMSE, although it was not significant. In this study, there was no association between serum vitamin D levels in older people with or without cognitive impairment.