Introduction: The increasing rate of prevalence of diabetes in the last 50 years make concerns on the remarkable dangers of diabetes for the population health.

Objectives: Regarding the importance of changing the serum creatinine level over time and limited data and information in Iran about the examining functional changes of creatinine level in diabetic patients, we designed this study for analyzing longitudinal data on serum creatinine.

Patients and Methods: Around 7778 cases, is gathered from suffering diabetes (type 2) and at least two times referral to the department during the survey period. To consider the ethical issues, only the information related to the biological correlation of the patients, without mentioning their name and features, has been used. Variables like sex, age, period of diabetes (the time distant between the diagnosis of the disease and the time of individuals’ participation in the survey), the type of treatment (the type of treatment they have achieved when they referred department), fasting blood sugar (FBS), blood urea nitrogen (BUN), body mass index (BMI), cholesterol, triglyceride, systolic blood pressure (SBP) and diastolic blood pressure (DBP) have been considered as independent variables and creatinine as dependent variable.

Results: After modifying time and other variables in the final model, only associations between changes of creatinine level with sex, age, period of diabetes, FBS and BMI remained significant.

Conclusion: This study showed the impact of gender, blood glucose control and weight on renal function and finally its effect on the survival of diabetic patients.