Incidence of type 2 diabetes by HbA1c and OGTT: the Isfahan Diabetes Prevention Study
The aim of this study was to estimate the incidence of type 2 diabetes using newly proposed hemoglobin A1C (HbA1c) and current oral glucose tolerance test (OGTT) definition in an Iranian non-diabetic population. A total of 923 non-diabetic first-degree relatives (FDRs) of patients with type 2 diabetes 30–70 years old in 2003–2005 were followed through 2009 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-h OGTT and HbA1c measurements. Prediction of progression to type 2 diabetes by OGTT-defined or HbA1c-defined diabetes was assessed with area under the receiver operating characteristic (ROC) curves based upon measurement of fasting plasma glucose, 2-h post-load glucose values, and HbA1c. The prevalence of type 2 diabetes was 9.2% (95% CI: 8.2, 10.2) by OGTT-defined diabetes and 7.9% (95% CI: 6.9, 9.0) by HbA1c ≥6.5. The incidence of type 2 diabetes was 2.0% (95% CI: 1.6, 2.4) (1.8% men and 2.1% women) per year by the current OGTT definition, whereas the incidence rates were 1.7% (95% CI: 1.3, 2.0) (1.6% men and 1.7% women) per year by HbA1c ≥6.5%. Of those diagnosed with type 2 diabetes by OGTT, 69.6% had HbA1c <6.5% and therefore would not have been classified as having type 2 diabetes. The incidence and prevalence of diabetes using newly proposed HbA1c threshold in this FDRs of patients with type 2 diabetes were slightly lower than using current OGTT definition.
Keywords: Type 2 diabetes; First-degree relatives; Diagnostic test; HbA1c; Glucose tolerance test
How to Cite
Janghorbani M, Amini M. Incidence of type 2 diabetes by HbA1c and OGTT: the Isfahan Diabetes Prevention Study. Acta Diabetol. 2012 Dec;49 Suppl 1:S73-9. doi: 10.1007/s00592-011-0260-6. Epub 2011 Feb 22. PMID: 21340503.