Infectious Disease Research Center (Brucellosis Reseach Center)

Famenin Brucellosis Cohort Study

Hamadan University of Medical Sciences, Infectious Disease Research Center(Brucellosis Research Center)

Principal Investigator:

Fariba Keramat(retired) *

Fatemeh Torkamanasadi **

*

Professor of Tropical and Infectious Diseases

Hamadan University of Medical Sciences

Director, Brucellosis Research Center

**

Assistant Professor of Infectious Disease

Infection Disease Research Center

Shahid Beheshti Medical Educational Center

Health Vice chancellor of Hamadan Universtiy of Medical Sciences

Approval date

11/01/2014

Approved the 617th meeting of the Research Council of the Vice Chancellor for Research and Technology of Hamadan University of Medical Sciences

Announcement session

15-7-2014

session for Announcement and introduction of cohort study

Coordination meeting

15-10-2014

Coordination meeting and profile review

Goals

Stage1: • To determination of brucellosis seroprevalence in Famenin populations. • To Identification and prioritization of risk factors. Stage2: • To determination the seroprevalence of brucellosis in the livestock population. • To identification of human and livestock species • To determine Antibiotic resistance. • To study the Prevalence of microbial contamination of dairy products. • To determine the pattern of disease transmission. • To Intervention to control, reduce, and prevent. Stage 3: • To evaluation of implementer intervention on brucellosis incidence.

Study population

Urban and rural population and livestock in Famenin city ,Hamadan province ,Iran

Sampling method and sample size

Two stage sampling (clusters were selected using systematic sampling) in Famenin city population for serologic investigation in 3161 persons were used. All cases of brucellosis will enroll in the study All brucellosis cases, infected livestock and dairy products in Famenin city will investigate

Starting date

Autumn 2014

Data Collection

The data in this study will be collected in three phases: Phase 1: Research was conducted to determine the serological status of human contamination and to identify and prioritize risk factors, and to record all cases of brucellosis. phase 2: In patients: clinical symptoms, transmission pattern, complications and recurrence, diagnostic and treatment methods, drug resistance will investigate. Investigations will be carried out to determine the serological status of livestock contamination. Educational interventions and vaccination of livestock will be done. Phase 3: Monitoring and intervention studies

Follow up Methods

Monitoring the clinical signs and seroprevalence of brucellosis in humans and livestock populations studied in Famenin during the study period.

Main Exposures

brucellosis Risk factors

Outcomes

Evaluation of subclinical and chronic brucellosis, relapse, complications, and drug resistance in the patients with brucellosis

cohort study

Staff

name
dr. Fariba Keramat
dr. Saeed Bashirian
dr, Manoochehr karami
dr.Abbas Moghimbeigi
dr.Mohammad Yousef Alikhani
dr. Saeed Khakizade
dr. Maryam Adabi
dr. Mehran Rajabi
dr. Mehdi Dinari
Zahra Shivapour

position
Administration Manager
Executive team member
Executive team member
Executive team member
Executive team member
Develop executive instructions for blood sampling and quality control
Head of Comprehensive Research Laboratory
Head of Famenin Health Center
Head of Famenin Health Center
MSC in epidemiology

name
Professor of Infectious Diseases
PhD in Health Education and Promotion
PhD in epidemiology
PhD in Biostatistics
PhD in microbioligy
Professional Doctor of Laboratory Sciences
PhD in microbioligy
General
Physician
General
Physician
supervisor, development instructions, quality control

Rationale and design paper

Keramat F, Karami M, Alikhani MY, Bashirian S, Moghimbeigi A, Adabi M. Cohort profile: Famenin Brucellosis Cohort Study. J Res Health Sci. 2019 Aug 3;19(3):e00453. PMID: 31586374; PMCID: PMC7183558.https://pubmed.ncbi.nlm.nih.gov/31586374/