Shahid Beheshti University of Medical Sciences Research Institute For Endocrine Sciences

Principal Investigator: Fahimeh Ramezani Tehrani

Professor of Obstetrics, Gynaecology and Reproductive Health -Shahid Beheshti University of Medical Sciences- Director, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences

June 11, 2013

June 11, 2013

To identify the prevalence of subclinical thyroid dysfunction in pregnancy (phase 1) and assessment of the effect of Levothyroxine on pregnancy outcomes of pregnant women with subclinical thyroid dysfunction

Pregnant women attending prenatal clinics under coverage of Shahid Beheshti University of Medical Sciences, Tehran, Iran

First phase: Stratified, multistage probability cluster sampling method (n=3000). Second phase: Randomized clinical trial; number of sample for each group=200

Interview, questionnaire, physical exam, collecting of blood and urine samples for assessment of serum levels of TSH, T4, T3uptake and TPOab and urinary iodine

– Active fallow-up every 3 months to repeat all measurements.
– Active follow up delivery and/or hospitalized events.

Serum levels of TSH, T4, T3 Uptake, TPO Ab and urinary Iodine

Pregnancy and newborn outcomes

Part Cohort

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