March 14, 2016

February 14, 2018

The Dena Non-Communicable Diseases cohort aims to investigate NCD risk factors for people aged 35-70 years in Dena settlement of Iran.

Main objectives:

A) To determine the incidence of major NCDs in people aged 35-70 years

B) To identify and measure the association between risk factors and NCDs

C) To determine the incidence of main outcomes related to NCDs and its related risk factors

D) To investigate associations of environmental and genetic/ethnic factors with the prevalence and incidence of NCDs and their outcomes

E) to examine the interplay between genetic/ethnic and environmental factors in the etiology and prevention of NCDs

F) to provide a research and education platform and a resource for national and international collaboration and to make the research community aware of the existence of large cohorts around the world

All eligible people between the ages of 35 and 70 living in Dena County

Convenient sampling by including 3630 resident of Dena

All data were collected based on the Persian cohort protocol. Individual and socioeconomic information, their exposure status including physical activity, nutrition, individual habits as well as information about their illnesses along with drug use and full examinations related to biochemical tests are performed and all information about their examinations are recorded. A sample of urine, nails and hair is also collected from all individuals.

The annual follow-up stage is to be conducted in both active and passive modes for next 15 years. In addition, full assessment (same as the recruitment phase) will be conducted three times; by 5-year interval. In the active follow-up, each participant will be contacted by telephone. The passive follow-up involves obtaining self-reports (whenever he/she visit the center) and annual reports from disease and death registries.

Main Exposures can be divided into 3 major sections: general, medical and nutritional including:

Questions on socio-economic status and lifestyle, Environmental and occupational exposures, General health and medical history, Blood, urine, hair and nail collection and analysis, Anthropometric measurements, Reproductive history, Nutritional status