Ardabil University of Medical Sciences

Digestive Disease Research Center

Principal Investigator: Dr. Farhad Pourfarzi

Professor of Community Medicine, Ardabil Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

17 March 2016

13 May 2017

Main objectives A) To determine the incidence of major NCDs in people aged 35-69 years B) To identify and measure the association between risk factors and GC C) To determine the etiology of GI cancers D) To stablish a Biobank for collected samples

All eligible people aged between ages of 35 and 69 living in Ardabil County

Convenient sampling method was used to recruit 10,000 resident of Ardabil city

All data were collected based on the Persian cohort protocol. People were interviewed in center to collect data about all risk factors of non-communicable diseases including Socio-economic status and lifestyle, Environmental and occupational exposures, General health and medical and family history, Anthropometric measurements, Reproductive history, Dietary habits. All the above-mentioned exposures collected using an internet-based questionnaire. Meanwhile blood, urine, hair and nail samples have been collected and kept in ultra-freezer.

Participants will be actively followed every 4 months. Additionally, a full assessment (as in the enrollment phase) will take place in two stages in a period of 5 years. In active follow up, each participant will be contacted by phone. Annual reports from diseases and deaths records will also be reviewed.

all risk factors of non-communicable diseases including: a. Socio-economic status and lifestyle b. Environmental and occupational exposures c. General health and medical and family history d. Anthropometric measurements e. Reproductive history f. Dietary habits

cardiovascular diseases, cerebrovascular accidents, cancers, diabetes mellitus, chronic pulmonary diseases, chronic kidney disease leading to dialysis, cirrhosis, Parkinson s and Alzheimer s diseases, hospital admission and deaths. In addition, Helicobacter pylori infection has been diagnosed using UBT and HP stool antigen.

Cohort Study


  • 17 March 2016

    Approval date

  • 13 May 2017

    Starting date

    13 May 2017

  • 19 March 2020

    End of enrollment phase

  • 18 September 2021

    Reassessment Date

    Milestone Content goes here

    18 September 2021