Principal Investigator:
Dr. Nader Saki
Associate Professor of Otolaryngology, hearing research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – Cohort study building, Hoveizeh city, Tel: 06136788141 – ahvaz.ent@gmail.com,saki-n@ajums.ac.ir, hoveizeh.cs@ajums.ac.ir
Approval date
14/03/2016 (2016 March 14)
Starting date
12/05/2016 (2016 May 12)
Goals
To determine prevalence and incidence rates of NCDs and trends of risk factors and their outcomes in Hoveizeh district
Study population
Adult people aged between 35-70 years.
Sampling method and sample size
All of 10000 eligible adults between 35-70 years old entered to the study by census method.
Data Collection
The exposures were measured by relevant standard tools and questionnaires. Data on general health, personal and working life history, medical examination, the frequency, prevalence, and history of NCDs, exposure to and risk factors for NCDs, lifestyle, physical activity, and nutrition (Food Frequency Questionnaire (FFQ)) were collected by electronic questionnaires. Blood, urine, hair, and nail specimens were gathered and stored in the HCS Biobank. For eye cohort eye exam, refractory error, funduscopic exam and retinal imaging, for ear cohort ear exam and audiometry is done. All steps of data collection and examinations were directly monitored by the quality control team.
Follow up Methods
In the follow up phase, subjects under study are followed in both active ways phone interview and passive ways by reports obtained through self-reports or disease registries centers, annually. To evaluate changes of risk and protective factors in second, third and fourth screening (fifth, tenth and fifteenth years later), measurement of anthropometric indices and blood, urine, hair and nail sampling will be done. Also lifestyle and nutrition questionnaire will be filled again. Death or unwillingness of individual to being under research will be consider as the end of study
Main Exposures
Main exposures for each participant were collected and recorded online through three general, nutritional and medical questionnaires and generally include the following: Demographic information (age, gender, socioeconomic status and job history, level of education),Life style, animal contact history, history of used fuel type, exposure to pesticides, physical activity and sleep status, frequency of feed intake and food habits, supplements consumption and amount of water used, History of diseases, reproductive history, evaluation of personal habits (alcohol and cigarettes), physical and oral examinations, measurements of anthropometric indices and blood pressure, pulse, biochemical and hematological measerments.
Outcomes
death (cause-specific death) and major non-communicable disease including cardiovascular risk factors and heart disease (such as hypertensive disease, myocardial infarction and ischemic heart diseases), cerebrovascular accidents (CVA, Stroke), cancers, diabetes mellitus, asthma , chronic obstructive pulmonary disease, pulmonary emphysema, kidney diseases that lead to dialysis, liver and gastrointestinal diseases like liver cirrhosis and trend of risk factors.
Cohort Study
HCS ducuments:
Rationale & Design papers
- paper 1: Prospective Epidemiological Research Studies in Iran (the PERSIAN CohortStudy): Rationale, Objectives, and Design
Poustchi H, Eghtesad S, Kamangar F, Etemadi A, Keshtkar AA, Hekmatdoost A, Mohammadi Z, Mahmoudi Z, Shayanrad A, Roozafzai F, Sheikh M, Jalaeikhoo A, Somi MH, Mansour-Ghanaei F, Najafi F, Bahramali E, Mehrparvar A, Ansari-Moghaddam A, Enayati AA, Esmaeili Nadimi A, Rezaianzadeh A, Saki N, Alipour F, Kelishadi R, Rahimi-Movaghar A, Aminisani N, Boffetta P, Malekzadeh R. Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design. Am J Epidemiol. 2018 Apr 1;187(4):647-655. doi: 10.1093/aje/kwx314. PMID: 29145581; PMCID: PMC6279089.
- paper 2: Cohort profile: The Hoveyzeh Cohort Study (HCS): A prospective population-based study on non-communicable diseases in an Arab community of Southwest Iran
Cheraghian B, Hashemi SJ, Hosseini SA, Poustchi H, Rahimi Z, Sarvandian S, Saki Malehi A, Alipour M, Eghtesad S, Fatahiasl J, Bayat A, Raji H, Saki N. Cohort profile: The Hoveyzeh Cohort Study (HCS): A prospective population-based study on non-communicable diseases in an Arab community of Southwest Iran. Med J Islam Repub Iran. 2020 Oct 21;34:141. doi: 10.34171/mjiri.34.141. PMID: 33437737; PMCID: PMC7787022.
HCS questionnaire
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Baseline phase
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Baseline questionnaire
- General questionnaire
- Medical questionnaire
- Nutritional questionnaire
- Eye questionnaire
- Ear questionnaire
- Lung questionnaire
- Heart questionnaire
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Follow-up phase
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Reassessment phase
HCS PIs
- Dr. Nader Saki:
Associate Professor of Otolaryngology, hearing research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – Cohort study building, Hoveizeh city, Tel: 06136788141 – ahvaz.ent@gmail.com,saki-n@ajums.ac.ir, hoveizeh.cs@ajums.ac.ir
- Dr.Seyed Jalal Hashemi
Professor of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Alimentary Tract Research Center Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences
- Dr.Bahman Cheraghian
Associate Professor of Epidemiology, Department of Biostatistics and Epidemiology, School of Health, Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences
- Dr.Seyed Ahmad Hosseini
Associate Professor of Clinical Biochemistry, Department of Nutritional Sciences, School of Allied Medical Sciences, Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Science
Headquarters staff
- Zahra Rahimi
- Sara Sarvandian
- Maedeh Raeisizadeh
- Amal Saki malehi
- Saeid Bitaraf
Cohort phases:
- Enrolment phase (Start: May/12/2016, End: August/22/2018)
- Follow-up phase (Start: November/22/2017)
- Re-assessment phase (Start: September/29/2021)
News
Publications
