Gholamreza Yousefzadeh(1), Mostafa Shokoohi(2), Hamid Najafipour(1),Mitra Shadkamfarokhi(1)


Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

1- Physiology Research Center, Institute of Nouropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2- Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Correspondence to: Mostafa Shokoohi, Email:


BACKGROUND: There has been a few studies about the predictability of metabolic syndrome
(MetS) based on the Framingham risk score (FRS) as a tool for predicting the risk of 10-years
cardiovascular diseases (CVD) in Iranian population. The aim of this study was to compare the
risk stratification obtained with the FRS and MetS in a cohort of the Iranian population.
METHODS: In this population-based study Kerman Coronary Artery Disease Risk study, Iran, MetS
was diagnosed as defined by the revised National Cholesterol Education Program definition criteria
(ATPIII) and the FRS was calculated using a computer program, previously reported algorithm.
RESULTS: Overall, the prevalence 10-years risk of CVD for patients with MetS was significantly
different with those without MetS (74.3 vs. 86.4% for low-risk patients, 18.1 vs. 12.3% for
intermediate-risk people, and 7.6 vs. 1.3% for high-risk individuals) (P < 0.001). The frequency
of intermediate-risk and high-risk for 10-year CVD in men with MetS (39.5 and 18.3%,
respectively) was considerably higher than women with MetS (3.2 and 0.1%, respectively). Using
multiple logistic regression, the odds ratio of MetS in intermediate-risk and high-risk FRS group
was 1.7 and 6.7, respectively (P < 0.001).
CONCLUSION: Significant association between the presence of MetS and high risk for CVD
based on FRS was revealed in both men and women indicating a good concordance between
MetS and FRS in predicting the risk of CVDs. However, the odds ratio of the development of risk
of cardiovascular events among women was higher than men with MetS.
Keywords: Metabolic Syndrome, Framingham Risk Score, Cardiovascular Disease, Ischemic
Heart Disease